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ABG shows pH 7.25, high CO2 — respiratory acidosis; increase ventilation. ABG interpretation (pH — acidosis <7.35/alkalosis >7.45; PaCO2 — respiratory — high = acidosis; HCO3 — metabolic; compensate — lungs/kidneys): respiratory acidosis (hypoventilation — increase ventilation), metabolic acidosis (lactate/DKA — treat cause + bicarbonate if severe). Ventilator (modes — AC — full support; SIMV — partial; PSV — spontaneous: lung-protective 6 ml/kg ideal body weight, PEEP; ARDS — low volume + prone). Vasopressors (norepinephrine — shock first-line; vasopressin/add-ons; dobutamine — cardiogenic). ICU care — sedation breaks, DVT prophylaxis, stress-ulcer prophylaxis, early mobilization. The ABG is the ventilator's report card — read it before touching settings.