High-performance liquid chromatography (HPLC)
Chromatography and Separation Techniques · Chemistry
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Interactive 3DBall-and-stick models with true bond angles — switch molecule to compare shapes.
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Study notes
Why is reverse-phase HPLC preferred for drug analysis? Step 1: Reverse phase: non-polar C18 stationary, polar mobile (water/acetonitrile). Step 2: Most drugs are moderately polar organics — separate well. Step 3: Water-based mobile phases are cheap, MS-compatible. Step 4: Versatility wins — reverse phase handles 80%+ of analyses!