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Emergency drugs: adrenaline, vasopressors, antidotes

Pharmacology · MBBS

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A paracetamol overdose patient arrives at 6 hours — N-acetylcysteine is started. Paracetamol poisoning kills the liver silently — N-acetylcysteine (NAC) replenishes glutathione, preventing hepatic necrosis; the Rumack-Matthew nomogram (level vs time) decides treatment. Give within 8 hours for best effect — but treat late presenters too. Activated charcoal only helps within 1 hour. The overdose that feels fine at hour 2 destroys at day 3 — time-based toxicology.

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