Enzymes: kinetics, inhibition, regulation, clinical enzymology
Biochemistry · MBBS
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Study notes
Aspirin permanently disables platelet COX enzymes. Aspirin is an irreversible inhibitor — it covalently acetylates cyclooxygenase's active site, killing the enzyme forever; the platelet (no nucleus, can't make new enzyme) is disabled for its 7–10 day life. This is why one low dose daily prevents clots — irreversible inhibition outlasts the drug in blood. Contrast reversible inhibitors (most drugs) that wash out. The inhibition type predicts the dosing — mechanism into prescription.
Related topics
- Biomolecules: carbohydrates — structure and classification
- Biomolecules: lipids — structure, classification, lipoproteins
- Biomolecules: proteins — structure, classification, amino acids
- Biomolecules: nucleotides, nucleic acids, DNA structure
- Bioenergetics: electron transport chain, oxidative phosphorylation
- Carbohydrate metabolism: glycolysis, TCA cycle, gluconeogenesis