Screening: validity of screening tests, natural history of disease
Community Medicine · MBBS
Study notes
A Pap smear camp detects cervical precancer in asymptomatic women. Screening works when disease has a detectable latent phase (cervical dysplasia → cancer over years), an acceptable test (Pap — cheap, simple), and effective early treatment (cryotherapy/LEEP). Sensitivity (catching disease) trades with specificity (avoiding false alarms) — the cut-off sets the balance. Lead-time bias warns: earlier detection isn't always longer life — randomized trials prove benefit. The smear that finds precancer is prevention wearing a lab coat.
Related topics
- Concepts of health and disease, levels of prevention
- Epidemiology: measures of disease frequency, study designs
- Epidemiology: outbreak investigation, epidemic curves
- Biostatistics: data types, sampling, tests of significance
- Communicable diseases: surveillance and control principles
- Non-communicable diseases: prevention and control programs