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Screening: validity of screening tests, natural history of disease

Community Medicine · MBBS

Study notes

A Pap smear camp detects cervical precancer in asymptomatic women. Screening works when disease has a detectable latent phase (cervical dysplasia → cancer over years), an acceptable test (Pap — cheap, simple), and effective early treatment (cryotherapy/LEEP). Sensitivity (catching disease) trades with specificity (avoiding false alarms) — the cut-off sets the balance. Lead-time bias warns: earlier detection isn't always longer life — randomized trials prove benefit. The smear that finds precancer is prevention wearing a lab coat.

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